Clayton has been in the comic book industry for 25 years. He is well known for his digital painted work on Marvel Comics books such as Venom vs Carnage (co-creator of Toxin), Ghost Rider, X-Force, and Carnage USA,  and also on the Valiant Comics series Rai. Crain is also known for his work with Todd McFarlane along with being an in-demand cover artist for DC & Marvel.